Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1.
Epstein-Barr virus Teaching Posters (EBV) has developed effective strategies to evade host innate immune responses.Here we reported on mitigation of type I interferon (IFN) production by EBV deubiquitinase (DUB) BPLF1 through cGAS-STING and RIG-I-MAVS pathways.The two naturally occurring forms of BPLF1 exerted potent suppressive effect on cGAS-STIN